Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 199, Issue 3, Pages 1052-1061Publisher
SPRINGERNATURE
DOI: 10.1007/s12011-020-02227-3
Keywords
Caffeic acid; Iron cardiotoxicity; Cardio-metabolism; Purinergic activity
Funding
- Research office, University of KwaZulu-Natal, Durban
- National Research Foundation - the World Academy of Science (NRF-TWAS), Pretoria, South Africa
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The study suggests that caffeic acid has a protective effect against iron-induced cardiotoxicity by suppressing oxidative imbalance and ACE activity, while modulating nucleotide hydrolysis and metabolic switch.
The protective effects of caffeic acid on angiotensin-converting enzyme (ACE) and purinergic enzyme activities, as well as gluconeogenesis was investigated in iron-induced cardiotoxicity. Cardiotoxicity was induced in heart tissues harvested from healthy male SD rats by 0.1 mM FeSO4. Treatment was carried out by co-incubating hearts tissues with caffeic acid and 0.1 mM FeSO4. Cardiotoxicity induction significantly (p < 0.05) depleted GSH level, SOD, catalase, and ENTPDase activities, with concomitant elevation of the levels of malondialdehyde (MDA), nitric oxide, ACE, ATPase, glycogen phosphorylase, glucose 6-phosphatase, fructose 6-biphsophatase, and lipase activities. There was significant (p < 0.05) reversion in these levels and activities on treatment with caffeic acid. Caffeic acid also caused depletion in cardiac levels of cholesterol, triglyceride, LDL-c, while elevating HDL-c level. Our results suggest the protective effect of caffeic acid against iron-mediated cardiotoxicity as indicated by its ability to suppress oxidative imbalance and ACE activity, while concomitantly modulating nucleotide hydrolysis and metabolic switch.
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