Journal
BIOESSAYS
Volume 42, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/bies.202000014
Keywords
high-level tigecycline resistance; pan-drug-resistant; plasmid reservoirs; plasmid-encoding tigecycline enzymatic inactivation; Tet(X); tetracycline antibiotics; tetracycline destructases
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Funding
- National Key Research and Development Program of China [2016YFD0501300]
- Program for Innovative Research Team in the University of Ministry of Education of China [IRT_17R39]
- Foundation for Innovation and Strengthening School Project of Guangdong, China [2016KCXTD010]
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Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next-generation tetracycline that is the final line of defense against severe infections by pan-drug-resistant bacterial pathogens. Unfortunately, this last-resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high-level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next-generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large-scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram-negative bacteria in both human and veterinary medicine.
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