Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1867, Issue 11, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2020.118800
Keywords
Acyl-CoA binding domain containing protein; Peroxisomes; Mitochondria; Lipid metabolism; Membrane contact sites; FFAT motif
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/N01541X/1, BB/R016844/1, BB/T002255/1]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [812968 PERICO]
- Canadian Institutes of Health Research - Graduate Scholarships - Doctoral [GSD-164257]
- Natural Sciences and Engineering Research Council of Canada Discovery grant [RGPIN-2020-05865]
- BBSRC [BB/R016844/1, BB/N01541X/1, BB/T002255/1] Funding Source: UKRI
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Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed membrane contact sites (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment.
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