Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1866, Issue 7, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2020.165758
Keywords
Chagas disease; Trypanosoma cruzi; Biomarkers; Host-derived; Treatment response; Disease prognosis
Funding
- Instituto de Salud Carlos III RICET Network for Cooperative Research in Tropical Diseases [ISCIII -RD12/0018/0010, PI1290]
- FEDER
- Departament d'Universitats i Recerca de la Generalitat de Catalunya, Spain (AGAUR) [2017SGR00924]
- Fundacio La Marato de TV3 [566/U/2018]
- Ministry of Health, Government of Catalunya [PERIS 2016-2010 SLT008/18/00132]
- Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 Program [CEX2018-000806-S]
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Chagas disease is caused by infection with the parasite Trypanosoma cruzi, which might lead to a chronic disease state and drive to irreversible damage to the heart and/or digestive tract tissues. Endemic in 21 countries in the Americas, it is the neglected disease with a highest burden in the region. Current estimates point at similar to 6 million people infected, of which similar to 30% will progress onto the symptomatic tissue disruptive stage. There is no vaccine but there are two anti-parasitic drugs available: benznidazole and nifurtimox. However, their efficacy is variable at the chronic symptomatic stage and both have frequent adverse effects. Since there are no prognosis markers, drugs should be administered to all T. cruzi-infected individuals in the indeterminate and early symptomatic stages. Nowadays, there are no tests-of-cure either, which greatly undermines patients follow-up and the search of safer and more efficacious drugs. Therefore, the identification and validation of biomarkers of disease progression and/or treatment response on which to develop tests of prognosis and/or cure is a major research priority. Both parasite- and host-derived markers have been investigated. In the present manuscript we present an updated outlook of the latter.
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