4.5 Article

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

Journal

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 16, Issue -, Pages 1305-1312

Publisher

BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.16.111

Keywords

C-H functionalization; continuous-flow; organic synthesis; photoredox catalysis; trifluoromethoxylation

Funding

  1. AbbVie
  2. China Scholarship Council (CSC)
  3. MINECO [BES-2017079784]
  4. European Union [794072]
  5. Marie Curie Actions (MSCA) [794072] Funding Source: Marie Curie Actions (MSCA)

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The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.

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