Journal
ARCHIVES OF VIROLOGY
Volume 165, Issue 10, Pages 2367-2372Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-020-04712-5
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Funding
- National Key Research and Development Program of China [2017YFD0500100, 2017YFD0501603]
- National Natural Science Foundation of China [31602072]
- Heilongjiang Science Foundation Project [C2018066, C2017079]
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Mammalian orthoreoviruses (MRVs) infect almost all mammals, and there are some reports on MRVs in China. In this study, a novel strain was identified, which was designated as HLJYC2017. The results of genetic analysis showed that MRV HLJYC2017 is a reassortant strain. According to biological information analysis, different serotypes of MRV contain specific amino acid insertions and deletions in the sigma 1 protein. Neutralizing antibody epitope analysis revealed partial cross-protection among MRV1, MRV2, and MRV3 isolates from China. L3 gene recombination in MRV was identified for the first time in this study. The results of this study provide valuable information on MRV reassortment and evolution.
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