4.6 Review

In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Cell stress in cortical organoids impairs molecular subtype specification

Aparna Bhaduri et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

Alex A. Pollen et al.

Article Genetics & Heredity

Identification of common genetic risk variants for autism spectrum disorder

Jakob Grove et al.

NATURE GENETICS (2019)

Article Multidisciplinary Sciences

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

Silvia Velasco et al.

NATURE (2019)

Article Multidisciplinary Sciences

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Daniel N. Weinberg et al.

NATURE (2019)

Review Neurosciences

Deconstructing cortical folding: genetic, cellular and mechanical determinants

Cristina Llinares-Benadero et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

N. Mellios et al.

MOLECULAR PSYCHIATRY (2018)

Review Genetics & Heredity

mTOR mutations in Smith-Kingsmore syndrome: Four additional patients and a review

G. Gordo et al.

CLINICAL GENETICS (2018)

Review Biochemistry & Molecular Biology

Neurogenesis impairment: An early developmental defect in Down syndrome

Fiorenza Stagni et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Biotechnology & Applied Microbiology

An in vivo model of functional and vascularized human brain organoids

Abed AlFatah Mansour et al.

NATURE BIOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Yingxiao Shi et al.

NATURE MEDICINE (2018)

Review Biochemistry & Molecular Biology

A History of the Pharmacological Treatment of Bipolar Disorder

Francisco Lopez-Munoz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Genetically engineered human cortical spheroid models of tuberous sclerosis

John D. Blair et al.

NATURE MEDICINE (2018)

Article Multidisciplinary Sciences

Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function

Lieselot L. G. Carrette et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

In vivo modeling of human neuron dynamics and Down syndrome

Raquel Real et al.

SCIENCE (2018)

Editorial Material Multidisciplinary Sciences

REVEALING THE BRAIN'S MOLECULAR ARCHITECTURE

Nenad Sestan

SCIENCE (2018)

Article Multidisciplinary Sciences

Microglia innately develop within cerebral organoids

Paul R. Ormel et al.

NATURE COMMUNICATIONS (2018)

Review Clinical Neurology

Clinical and biological progress over 50 years in Rett syndrome

Helen Leonard et al.

NATURE REVIEWS NEUROLOGY (2017)

Editorial Material Clinical Neurology

Global analysis of neurological disease: burden and benefit

[Anonymous]

LANCET NEUROLOGY (2017)

Article Multidisciplinary Sciences

Cell diversity and network dynamics in photosensitive human brain organoids

Giorgia Quadrato et al.

NATURE (2017)

Article Biochemical Research Methods

Generation of pure GABAergic neurons by transcription factor programming

Nan Yang et al.

NATURE METHODS (2017)

Review Clinical Neurology

Autosomal Recessive Primary Microcephaly (MCPH): An Update

Sami Zaqout et al.

NEUROPEDIATRICS (2017)

Article Genetics & Heredity

17p13.3 Microdeletion: Insights on Genotype-Phenotype Correlation

Marshall I. Barros Fontes et al.

MOLECULAR SYNDROMOLOGY (2017)

Review Cell Biology

Rodent models in Down syndrome research: impact and future opportunities

Yann Herault et al.

DISEASE MODELS & MECHANISMS (2017)

Article Cell & Tissue Engineering

Induction of Expansion and Folding in Human Cerebral Organoids

Yun Li et al.

CELL STEM CELL (2017)

Article Biotechnology & Applied Microbiology

Generation of serotonin neurons from human pluripotent stem cells

Jianfeng Lu et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Xuyu Qian et al.

Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

Review Cell & Tissue Engineering

Stem Cell Models of Human Brain Development

Iva Kelava et al.

CELL STEM CELL (2016)

Article Cell & Tissue Engineering

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

Hengli Tang et al.

CELL STEM CELL (2016)

Article Biochemistry & Molecular Biology

Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome

Samantha D. McElyea et al.

HUMAN MOLECULAR GENETICS (2016)

Article Biochemistry & Molecular Biology

The promises and challenges of human brain organoids as models of neuropsychiatric disease

Giorgia Quadrato et al.

NATURE MEDICINE (2016)

Article Multidisciplinary Sciences

Zika virus impairs growth in human neurospheres and brain organoids

Patricia P. Garcez et al.

SCIENCE (2016)

Article Geriatrics & Gerontology

Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease

Ioannis U. Isaias et al.

FRONTIERS IN AGING NEUROSCIENCE (2016)

Review Biochemical Research Methods

Microfluidic 3D cell culture: from tools to tissue models

Vincent van Duinen et al.

CURRENT OPINION IN BIOTECHNOLOGY (2015)

Article Biochemistry & Molecular Biology

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

Jae Seok Lim et al.

NATURE MEDICINE (2015)

Article Biochemical Research Methods

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

Anca M. Pasca et al.

NATURE METHODS (2015)

Article Multidisciplinary Sciences

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

J. Gray Camp et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Multidisciplinary Sciences

Genetics and genomics of psychiatric disease

Daniel H. Geschwind et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors

Reuven Edri et al.

NATURE COMMUNICATIONS (2015)

Article Multidisciplinary Sciences

Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

Zhong-Wei Du et al.

NATURE COMMUNICATIONS (2015)

Article Developmental Biology

mTOR regulates brain morphogenesis by mediating GSK3 signaling

Minhan Ka et al.

DEVELOPMENT (2014)

Article Biochemistry & Molecular Biology

Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome

Yi-Ru Yu et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biotechnology & Applied Microbiology

Microfluidic organs-on-chips

Sangeeta N. Bhatia et al.

NATURE BIOTECHNOLOGY (2014)

Article Biochemical Research Methods

Generation of cerebral organoids from human pluripotent stem cells

Madeline A. Lancaster et al.

NATURE PROTOCOLS (2014)

Article Multidisciplinary Sciences

Translating dosage compensation to trisomy 21

Jun Jiang et al.

NATURE (2013)

Article Multidisciplinary Sciences

Cerebral organoids model human brain development and microcephaly

Madeline A. Lancaster et al.

NATURE (2013)

Review Neurosciences

Twenty-Five Years of Progress: The View from NIMH and NINDS

Thomas R. Insel et al.

NEURON (2013)

Article Multidisciplinary Sciences

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

Taisuke Kadoshima et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Deficits in human trisomy 21 iPSCs and neurons

Jason P. Weick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Genetics & Heredity

DISEASE MECHANISMS Genetic architectures of psychiatric disorders: the emerging picture and its implications

Patrick F. Sullivan et al.

NATURE REVIEWS GENETICS (2012)

Editorial Material Multidisciplinary Sciences

iPSC Disease Modeling

Frank Soldner et al.

SCIENCE (2012)

Article Cell Biology

Revolution Stalled

Steven E. Hyman

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Psychiatry

X-Chromosome Inactivation in Rett Syndrome Human Induced Pluripotent Stem Cells

Aaron Y. L. Cheung et al.

Frontiers in Psychiatry (2012)

Article Biotechnology & Applied Microbiology

Specification of transplantable astroglial subtypes from human pluripotent stem cells

Robert Krencik et al.

NATURE BIOTECHNOLOGY (2011)

Article Multidisciplinary Sciences

Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome

Kun-Yong Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

Maria C. N. Marchetto et al.

Review Pediatrics

Clinical practice The care of children with Down syndrome

Michel E. Weijerman et al.

EUROPEAN JOURNAL OF PEDIATRICS (2010)

Article Multidisciplinary Sciences

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

Jeremy N. Pulvers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biotechnology & Applied Microbiology

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Stuart M. Chambers et al.

NATURE BIOTECHNOLOGY (2009)

Review Genetics & Heredity

Genetic disorders associated with macrocephaly

Charles A. Williams et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2008)

Article Neurosciences

Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome

L. Medrihan et al.

JOURNAL OF NEUROPHYSIOLOGY (2008)

Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Kazutoshi Takahashi et al.

Article Cell Biology

The mouse ascending: perspectives for human-disease models

Nadia Rosenthal et al.

NATURE CELL BIOLOGY (2007)

Article Neurosciences

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome

Fabian Fernandez et al.

NATURE NEUROSCIENCE (2007)

Article Neurosciences

Pten regulates neuronal arborization and social interaction in mice

Chang-Hyuk Kwon et al.

NEURON (2006)

Article Dermatology

Clinical and histopathological findings in Bannayan-Riley-Ruvalcaba syndrome

E Erkek et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2005)

Review Genetics & Heredity

Autosomal recessive primary microcephaly (MCPH): A review of clinical, molecular, and evolutionary findings

CG Woods et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2005)

Article Neurosciences

Directed differentiation of telencephalic precursors from embryonic stem cells

K Watanabe et al.

NATURE NEUROSCIENCE (2005)

Review Genetics & Heredity

Genome-wide association studies for common diseases and complex traits

JN Hirschhorn et al.

NATURE REVIEWS GENETICS (2005)

Review Genetics & Heredity

Miller-Dieker syndrome: Analysis of a human contiguous gene syndrome in the mouse

J Yingling et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2003)

Article Biotechnology & Applied Microbiology

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

QL Ying et al.

NATURE BIOTECHNOLOGY (2003)

Article Biotechnology & Applied Microbiology

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

SC Zhang et al.

NATURE BIOTECHNOLOGY (2001)