Stable clinical long term results after AMIC in the aligned knee

Introduction The aim of this study was to report a long-term follow-up of patients treated with autologous matrix-induced chondrogenesis (AMIC) for full-thickness chondral and osteochondral defects of the femoral condyle or patella combined with the correction of lower limb malalignment or patellar tracking if indicated. Methods Thirty-three patients (thirty-four knees) were treated surgically for chondral and osteochondral cartilage defects of the knee joint. Regarding the origin of the lesion, patients were divided into three groups. Chondral lesions were observed in the patella (cP group) in fifteen patients, whereas eight patients demonstrated a femoral condylar location (cF group). Eleven patients presented with osteochondritis dissecans of the femur (ocF group). Associated procedures involving realignment of the patella, osteotomy around the knee, or cancellous bone grafting were performed when necessary. The mean size of the lesions was 2.8 +/- 1.6 cm(2), and the mean patient age was 37.1 +/- 11.9 years. To evaluate the clinical outcomes, the Lysholm score and the VAS pain score were imposed, as well as the reoperation rate. Results After an average of 9.3 +/- 1 years, follow-up was completed in 79% of the patients. Two patients from the cohort received a total knee prosthesis. The primary outcome measures (Lysolm and VAS pain) at 9-year follow-up were 85 +/- 13 for the Lysholm score and 1.9 +/- 1.6 for the VAS score in the entire analyzed population. Compared to the preoperative values (Lysholm 56 +/- 19, VAS 5.8 +/- 2.4) and the 2-year results (Lysholm 85 +/- 16, VAS 2.0 +/- 2.1), there was significant improvement in the first 2 years after intervention and a stable course in the long-term observation. The same was observed in the cP and ocF subgroups, whereas patients of the cF group showed even further improvement. Conclusions AMIC showed durable results in aligned knees. The favorable outcome was maintained after an average of 9 years when malalignment of the lower limb and patellar maltracking were corrected. Such data are particularly encouraging for young adult patients who may benefit from a procedure that circumvents early arthroplasty.

Automated summary

This study aimed to evaluate the long-term outcomes of AMIC treatment for full-thickness chondral and osteochondral defects. The results showed durable clinical improvement in most patients after 9 years, especially when lower limb malalignment and patellar tracking were corrected. This data suggests young adult patients may benefit from AMIC as an alternative to early arthroplasty.