Journal
APPLIED CATALYSIS B-ENVIRONMENTAL
Volume 269, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apcatb.2020.118848
Keywords
Graphitic carbon nitride; Photodynamic therapy; Reactive oxide species; Synergetic effects; Bandgap modification
Funding
- National Natural Science Foundations of China [11874200, 11574138, 11934009, 11674173, 11874216]
- Top-Notch Young Talents Program of China
- National Key R&D Program of China [2016YFA0201104]
- Dengfeng Project B of Nanjing University
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Graphitic Carbon Nitride (g-C3N4) has extensive application prospect of photodynamic therapy (PDT), which can be attributed to the biocompatibility and photosensitivity. However, it suffers from the near-ultraviolet absorption edge and low reactive oxygen species (ROS) release rate. This work exhibits an atomic-thickness water-soluble g-C3N4 with alkali Zn (2+) and K(+ )modification (MCN), whose absorption edge is tuned from 460 nm for GCN to the entire visible-light region (663 nm), and bandgap is reduced to 1.94 eV. Both K+- bridging intercalation and the in-plane Zn-N significantly enhance the photocatalytic performance, as well as inhibit the overexpression of glutathione (GSH) significantly. The synergistic effect make that the release rate of ROS is about 45.16 % (7.95 % for pristine g-C3N4), accomplishing a considerable inactivation efficiency of malignant melanoma A375. This work fundamentally releases the limitation of g-C3N4 as a PDT photosensitizer, revealing its multifunctional promise to cancer therapy.
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