Journal
CHINESE JOURNAL OF POLYMER SCIENCE
Volume 34, Issue 6, Pages 679-687Publisher
SPRINGER
DOI: 10.1007/s10118-016-1787-3
Keywords
Waterborne polyurethane; Heparin; Blend coating; Hemocompatibility
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Funding
- National Natural Science Foundation of China [51173118, 51273124, 51273126]
- National Science Fund for Distinguished Young Scholars of China [51425305]
- Youth Science and Technology Innovation Team of Sichuan Province [2015TD0001]
- State Key Laboratory of Polymer Materials Engineering [sklpme2014-2-03]
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In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane (WPU)/heparin release coating system (WPU/heparin) is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), thrombin time (TT), hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.
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