4.8 Article

Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 40, Pages 17447-17450

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007315

Keywords

imaging; lipids; mass spectrometry; morphometry; single-cell analysis

Funding

  1. Dutch province of Limburg as part of the LINK program
  2. National Institutes of Health (NIH) of the United States of America [NIH R01 CA213492]
  3. European Union (ERA-NET TRANSCAN 2) [643638]
  4. Joint Imaging Valley program of the University of Liege
  5. Joint Imaging Valley program of the Maastricht University

Ask authors/readers for more resources

The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available