Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 40, Pages 17447-17450Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007315
Keywords
imaging; lipids; mass spectrometry; morphometry; single-cell analysis
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Funding
- Dutch province of Limburg as part of the LINK program
- National Institutes of Health (NIH) of the United States of America [NIH R01 CA213492]
- European Union (ERA-NET TRANSCAN 2) [643638]
- Joint Imaging Valley program of the University of Liege
- Joint Imaging Valley program of the Maastricht University
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The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.
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