Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 24, Pages 13198-13224Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008166
Keywords
asymmetric catalysis; cyclopentadienyl ligands; enantioselective synthesis; homogeneous catalysis; metal complex
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Funding
- EPFL
- Swiss National Science Foundation [157741]
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The development of new chiral ligands is crucial for stereocontrol in metal-catalyzed reactions, especially with the increasing demand for bioactive molecules as single enantiomers. The successful application of Cp-X ligands in metal-catalyzed transformations allows access to valuable chiral molecules, with critical comparisons of existing ligand families and discussion of future research directions for further enhancing their performance and application in enantioselective catalysis.
The creation of new chiral ligands capable of providing high stereocontrol in metal-catalyzed reactions is crucial in modern organic synthesis. The production of bioactive molecules as single enantiomers is increasingly required, and asymmetric catalysis with metal complexes constitutes one of the most efficient synthetic strategies to access optically active compounds. Herein we offer a historical overview on the development of chiral derivatives of the ubiquitous cyclopentadienyl ligand (Cp-X), and detail their successful application in a broad range of metal-catalyzed transformations. Those include the functionalization of challenging C-H bonds and beyond, giving access to an extensive catalogue of valuable chiral molecules. A critical comparison of the existing ligand families, their design, synthesis, and complexation to different metals is also provided. In addition, future research directions are discussed to further enhance the performance and application of Cp-X ligands in enantioselective catalysis.
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