Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 41, Pages 18267-18271Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008897
Keywords
aldehydes; nickel; phenols; photocatalysis; radical chemistry
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Funding
- JSPS KAKENHI [15H05756, 18H04648, 20H04810]
- Grants-in-Aid for Scientific Research [18H04648, 20H04810] Funding Source: KAKEN
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A convenient method is reported to specifically acylate phenolic hydroxyl groups through a radical pathway. When a mixture of an aldehyde and a phenol in ethyl acetate is irradiated with blue light in the presence of iridium and nickel bromide catalysts at ambient temperature, phenoxyl and acyl radicals are transiently generated in situ and cross-couple to furnish an ester. Aliphatic hydroxy groups remain untouched under the reaction conditions.
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