Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 48, Pages 21431-21435Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008224
Keywords
endogenous CO; fluorescence; ruthenium; sensing; viscosity
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Funding
- EPSRC [EP/I003983/1, EP/L015226/1]
- EPSRC [EP/I003983/1] Funding Source: UKRI
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A new family of robust, non-toxic, water-compatible ruthenium(II) vinyl probes allows the rapid, selective and sensitive detection of endogenous carbon monoxide (CO) in live mammalian cells under normoxic and hypoxic conditions. Uniquely, these probes incorporate a viscosity-sensitive BODIPY fluorophore that allows the measurement of microscopic viscosity in live cells via fluorescence lifetime imaging microscopy (FLIM) while also monitoring CO levels. This is the first example of a probe that can simultaneously detect CO alongside small viscosity changes in organelles of live cells.
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