Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 45, Pages 19825-19829Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202001124
Keywords
automation; chemoenzymatic synthesis; machine-driven; peptide synthesizer; silica resin
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Funding
- National Institutes of Health [U01GM116263]
- Shanghai Institute of Materia Medica [2019000021]
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Historically, researchers have put considerable effort into developing automation systems to prepare natural biopolymers such as peptides and oligonucleotides. The availability of such mature systems has significantly advanced the development of natural science. Over the past twenty years, breakthroughs in automated synthesis of oligosaccharides have also been achieved. A machine-driven platform for glycopeptide synthesis by a reconstructed peptide synthesizer is described. The designed platform is based on the use of an amine-functionalized silica resin to facilitate the chemical synthesis of peptides in organic solvent as well as the enzymatic synthesis of glycan epitopes in the aqueous phase in a single reaction vessel. Both syntheses were performed by a peptide synthesizer in a semiautomated manner.
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