Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 43, Pages 19222-19228Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202007825
Keywords
cascade reaction; iron catalysis; N-heterocycles; oximes; synthetic methods
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Funding
- NSFC [21772231]
- National Key R&D program of China [2018YFA0507900]
- China Postdoctoral Science Foundation [2018M633761]
- Army Medical University
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By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series of structurally novel and interesting azepine and spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl(2)as the catalyst and readily available oximes as five-atom units, while showcasing broad substrate scope and good functional group compatibility. The annulation products can be easily converted into many valuable compounds. Moreover, DFT calculation studies are performed to provide some insights into the possible reaction mechanisms for the (5+2) and (5+1) annulations.
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