Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 38, Pages 16381-16384Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202005111
Keywords
ferroptosis; immunogenic cell death; immunotherapy; manganese oxide; nanovaccines
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Funding
- National Natural Science Foundation of China
- NSFC [51720105015, 51672269, 51929201, 51922097, 51772124, 51872282]
- Science and Technology Cooperation Project between Chinese and Australian Governments [2017YFE0132300]
- Key Research Program of Frontier Sciences, CAS [YZDY-SSW-JSC018]
- Youth Innovation Promotion Association of CAS [2017273]
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Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, the intrinsic immunogenicity of MONs is still unclear. MnO(x)nanospikes (NSs) as tumor microenvironment (TME)-responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine-based immunotherapy. MnO(x)NSs with large mesoporous structures show ultrahigh loading efficiencies for ovalbumin and tumor cell fragment. The combination of ICD via chemodynamic therapy and ferroptosis inductions, as well as antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, the obtained nanovaccines achieve TME-responsive magnetic resonance/photoacoustic dual-mode imaging contrasts, while effectively inhibiting primary/distal tumor growth and tumor metastasis.
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