Etiologies of sperm DNA damage and its impact on male infertility

Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is considered the cornerstone of laboratory evaluation of male infertility, but it has its own drawbacks and fails to predict the male fertility potential with high sensitivity and specificity. Different etiologies have been linked with male infertility, of which sperm DNA damage has gained significant attention with extensive research on sperm function tests. The associations between sperm DNA damage and a variety of disorders such as varicocele, obesity, cancer, radiation and lifestyle factors are explored in this review. Furthermore, we discuss the mechanisms of DNA damage as well as its impact in different scenarios of male infertility, associated with spontaneous and assisted reproduction. Finally, we review the clinical applicability of sperm DNA fragmentation testing in the management of male infertility.

Automated summary

Male factor accounts for up to 50% of infertility cases worldwide, with semen analysis being the cornerstone of evaluation but limited in predicting fertility potential. Sperm DNA damage has received significant attention and is associated with various disorders including varicocele, obesity, and cancer. The clinical applicability of sperm DNA fragmentation testing in managing male infertility is discussed.