Journal
ANALYTICAL SCIENCES
Volume 36, Issue 8, Pages 923-934Publisher
JAPAN SOC ANALYTICAL CHEMISTRY
DOI: 10.2116/analsci.20R002
Keywords
Biosensors; cells; pattern recognition; polymers; nanoparticles; sensor arrays; multivariate analysis; diagnosis
Categories
Funding
- AMED [JP17be0304101]
- JSPS under KAKENHI Grant [JP17H04884]
- DAICENTER project grant from the DBT (Govt. of India)
- AIST (Japan)
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To capture a broader scope of complex biological phenomena, alternatives to conventional sensing based on specificity for cell detection and characterization are needed. Pattern-recognition-based sensing is an analytical method designed to mimic mammalian sensory systems for analyte identification based on the pattern recognition of multivariate data, which are generated using an array of multiple probes that cross-reactively interact with analytes. This sensing approach is significantly different from conventional specific cell sensing based on highly specific probes, including antibodies against biomarkers. Encouraged by the advantages of this technique, such as the simplicity, rapidity, and tunability of the systems without requiring a priori knowledge of biomarkers, numerous sensor arrays have been developed over the past decade and used in a variety of cell sensing applications; these include disease diagnosis, drug discovery, and fundamental research. This review summarizes recent progress in pattern-recognition-based cell sensing, with a particular focus on guidelines for designing materials and arrays, techniques for analyzing response patterns, and applications of sensor systems that are focused primarily for the biomedical field.
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