Journal
ANALYTICAL CHEMISTRY
Volume 92, Issue 17, Pages 12002-12009Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c02509
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Funding
- National Science Foundation of China [21572209, 21907025]
- Scientific and Technological Project of Henan Province of China [192102310140]
- Scientific and Technological Innovation Project of Henan Academy of Agricultural Sciences [2020CX05]
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Mercury (Hg) is considered an extremely toxic heavy metal which is extremely harmful to both the human body and environment. In addition, Hg2+-induced oxidative stress also exerts a crucial role to play in pathophysiological mechanisms of mercury toxicity. Thus, efficient and specific fluorescent probes for imaging He -induced oxidative stress are necessary. In the present study, we rationally design a novel Hg2+-activated and ICT-based NIR emission fluorescent probe NIR-HO for sequentially monitoring the ONOO- level with a dual-key-and-lock strategy. The probe NIR-HO showed rapid response and excellent specificity and sensitivity for the detection of Hg2+ and ONOO- in vitro. Cell imaging demonstrated that Hg2+-induced oxidative stress was involved in ONOO- upregulation. Also, GSH, NAC, and EDTA were employed as excellent detoxifying drugs against Hg2+-induced toxicity. Moreover, the probe NIR-HO was successfully used for imaging Hg2+ and ONOO- in vivo. In brief, NIR-HO provides a simple and powerful approach which can be used to image Hg2+-induced oxidative stress in the pathological environment.
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