Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 319, Issue 2, Pages E363-E375Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00362.2019
Keywords
adipokines; adipose tissue; cardiac remodeling; diabetes; metabolic syndrome
Categories
Funding
- National Institutes of Health (NIH) [R01-HL-131613]
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Bone morphogenetic protein (BMP) receptor signaling is critical for the regulation of the endocrine system and cardiovascular structure and function. The objective of this study was to investigate whether Bmp3b, a glycoprotein synthetized and secreted by adipose tissue, is necessary to regulate glucose and lipid metabolism, adipogenesis, and cardiovascular remodeling. Over the course of 4 mo, Bmp3b-knockout (Bmp3b(-/-)) mice gained more weight than wild-type (WT) mice. The plasma levels of cholesterol and triglycerides were higher in Bmp3b(-/-) mice than in WT mice. Bmp3b(-/-) mice developed insulin resistance and glucose intolerance. The basal heart rate was higher in Bmp3b(-/-) mice than in WT mice, and echocardiography revealed eccentric remodeling in Bmp3b' mice. The expression of adipogenesis-related genes in white adipose tissue was higher in Bmp3b(-/-) mice than in WT control mice. In vitro studies showed that Bmp3b modulates the activity of the C/ebp alpha promoter. an effect mediated by Smad2/3. The results of this study suggest that Bmp3b is necessary for the maintenance of homeostasis in terms of age-related weight gain, glucose metabolism, and left ventricular (LV) remodeling and function. Interventions that increase the level or function of BMP3b may decrease cardiovascular risk and pathological cardiac remodeling.
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