Journal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 319, Issue 4, Pages C624-C629Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00303.2020
Keywords
brain; degradation; microRNA; stability; TDMD
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Funding
- National Institute on Aging [AG0336]
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MicroRNAs (miRNAs) are short, noncoding RNAs that are evolutionarily conserved across many different species. miRNA regulation of gene expression, specifically in the context of the mammalian brain, has been well characterized; however, the regulation of miRNA degradation is still a focus of ongoing research. This review focuses on recent findings concerning the cellular mechanisms that govern miRNA degradation, with an emphasis on target-mediated miRNA degradation and how this phenomenon is uniquely poised to maintain homeostasis in neuronal systems.
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