Journal
CHINESE JOURNAL OF CHEMISTRY
Volume 34, Issue 6, Pages 594-598Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201500733
Keywords
cyanine; GSH detection; near-infrared fluorescence; bioimaging
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Funding
- National Natural Science Foundation of China [21272088, 21472059, 21402057, 81371684]
- Program for Academic Leader in Wuhan Municipality [201271130441]
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Amino acids containing the thiol group play significant roles in keeping biological oxidation reduction balance. Due to the important cellular function of biothiols, it is imperative to develop efficient methods to detect biothiols in complicate biological systems. In this work, we developed a cyanine-based fluorescent probe utilizing thioether as a detecting group, which showed the fluorescent turn-on response towards GSH and it can be used as a biomarker to determine the cellular GSH.
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