4.5 Article

Rhodium(III)/Amine Synergistically Catalyzed Enantioselective Alkylation of Aldehydes with α,β-Unsaturated 2-Acyl Imidazoles

Journal

CHINESE JOURNAL OF CHEMISTRY
Volume 34, Issue 12, Pages 1225-1235

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201600592

Keywords

alkylation of aldehyde; chiral-at-metal complex; synergistic catalysis

Funding

  1. National Natural Science Foundation of China [21302183]
  2. Strategic Priority Research Program of the Chinese Academy of Sciences [XDA09030102]
  3. 100 Talents Programme of the Chinese Academy of Sciences

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A synergistic catalysis combination of chiral-at-metal rhodium complex and amine catalyst was developed for enantioselective alkylation of aldehydes with alpha,beta-unsaturated 2-acyl imidazoles. The corresponding adducts were obtained in good yields with excellent enantioselectivities (up to 99% ee).

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