Journal
ALZHEIMERS & DEMENTIA
Volume 17, Issue 1, Pages 18-28Publisher
WILEY
DOI: 10.1002/alz.12171
Keywords
biomarkers; cerebral small vessel disease; Chinese; cognitive aging; cohort; dementia; longitudinal study; mild cognitive impairment; neuroepidemiology; prevention
Categories
Funding
- National Key Research and Development Programof China [2017YFC0907000, 2017YFC0907500]
- National Natural Science Foundation of China [91846302]
- International Science and Technology Cooperation Programof China [2014DFA32830]
- Key Research and Development Plans of Jiangsu Province [BE2016726]
- Science and Technology Commission of Shanghai Municipality [16JC1400501]
- Shanghai Municipal Science and Technology Major Project [2017SHZDZX01]
- China Postdoctoral Science Foundation [2019M661376]
- Key Technology Research and Development Program of Taizhou [TS201833]
- 111 Project of China [B13016]
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China has the highest number of dementia patients globally, but research in this area is still lacking. Due to differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other populations, it is crucial to establish long-term infrastructure for advancing research on cognitive aging and dementia in China.
China has the largest number of patients with dementia in the world. However, dementia in the Chinese population is still poorly understood and under-researched. Given the differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other ethnic/racial groups, it is crucial to build appropriate infrastructure for long-term longitudinal studies to advance Chinese cognitive aging and dementia research. We initiated a community-based prospective cohort-the Taizhou Imaging Study (TIS)-to accelerate the understanding of dementia and cerebrovascular diseases in Chinese. This article presents the rationale, aims, study design, and organization of TIS. In addition, we described some examples of the types of studies such a resource might support. The TIS provides a new framework for facilitating Chinese dementia research, encompassing invaluable resources including detailed epidemiological, sociocultural, neuroimaging, and omics data.
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