Journal
ALZHEIMERS & DEMENTIA
Volume 16, Issue 7, Pages 1078-1094Publisher
WILEY
DOI: 10.1002/alz.12123
Keywords
Alzheimer's disease; cognitive impairment; dementia; lifestyle; multidomain intervention; prevention; randomized controlled trial; World-Wide FINGERS
Categories
Funding
- Swedish Research Council [529-2014-7503, 2017-00740, 201705819, 2017-06105]
- French National Agency for Research [ANR-14-JPPS-0001-02]
- JuhoVainio Foundation
- Finnish Medical Foundation
- Finnish Social Insurance Institution
- Ministry of Education and Culture Research Grant
- Finnish Cultural Foundation
- Knut and AliceWallenberg Foundation
- Center for Innovative Medicine
- Karolinska Institutet Sweden
- Stiftelsen Stockholms sjukhem Sweden
- Konung GustafV:s och DrottningVictorias Frimurarstiftelse Sweden
- af Jochnick Foundation Sweden
- Alzheimer's Research and Prevention Foundation
- European Research Council [ERC-804371]
- Alzheimerfonden Sweden
- Region Stockholm
- National Institutes of Health [R01AG062689]
- Wake Forest Alzheimer's Disease CoreCenter [P30AG04963801A1]
- National Health and Medical Research [APP1095097]
- Centre For HealthyAgeing
- Japan Agency forMedical Research andDevelopment
- Canadian Institutes of Health Research [201901CNA-417847-CAN-ABPI32054]
- Centre forBrain Research
- Alzheimer's Association [18PTCR-592192]
- Instituto Carlos III [PI17/00223]
- NationalKeyR&D Programof China
- Ministry of Science and Technology of China [2017YFC1310100]
- National Natural Science Foundation of China [81861138008]
- Joint China-Sweden MobilityProgrammegrants from the National Natural Science Foundation of China
- NSFC [8191101618]
- Swedish Foundation for International Cooperation
- Research and Higher Education [CH2019-8320]
- National University Health System
- Agence Nationale de la Recherche (ANR) [ANR-14-JPPS-0001] Funding Source: Agence Nationale de la Recherche (ANR)
- Swedish Research Council [2017-06105] Funding Source: Swedish Research Council
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Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
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