Gold-Catalyzed Aminoaromatizations of 1,2-Bis(alkynyl)benzenes with Anthranils to Yield 1-Amino-2-napthaldehyde Products

Gold-catalyzed aminoaromatizations of 1,n-diynes with anthranils afforded 1-amino-2-napthaldehyde derivatives efficiently. In this reaction sequence, anthranils preferably attack at gold-coordinated prop-3-yn-1-ols to generate alpha-imino gold carbenes that enable subsequent cyclizations with the other alkynes. Chemical functionalizations of the resulting 1-amino-2-napthaldehydes are presented to manifest the synthetic utility of these reactions.