Journal
ADVANCED MATERIALS
Volume 32, Issue 37, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202003382
Keywords
aggregation-induced emission; black phosphorus nanosheets; cancer theranostics; dual-modal imaging; synergistic therapy
Categories
Funding
- China Postdoctoral Science Foundation [2019M663066]
- Natural Science Foundation for Distinguished Young Scholars of Guangdong Province [2020B1515020011]
- Natural Science Foundation of China [21801169]
- Science and Technology Foundation of Shenzhen City [JCYJ20190808153415062]
- Natural Science Foundation of Guangdong Province [2018A0303130081]
- Natural Science Foundation of Shenzhen University [2019004]
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Inspired by the respective advantages of aggregation-induced emission (AIE)-active photosensitizers and black phosphorus nanomaterials in cancer treatment, the facile construction of novel AIE photosensitizers married to 2D black phosphorus nanosheets and their application for multimodal theranostics are demonstrated. The developed nanomaterial simultaneously possesses distinctive properties and multiple functions including excellent stability, good biocompatibility, intensive fluorescence emission in the NIR region, high-performance reactive oxygen species generation, good photothermal conversion efficiency, outstanding cellular uptake, and effective accumulation at the tumor site. Both in vitro and in vivo evaluation show that the presented nanotheranostic system is an excellent candidate for NIR fluorescence-photothermal dual imaging-guided synergistic photodynamic-photothermal therapies. This study thus not only extends the applications scope of AIE and black phosphorus materials, but also offers useful insights into designing a new generation of cancer theranostic protocol for potential clinical applications.
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