Journal
ADVANCED MATERIALS
Volume 32, Issue 37, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202000866
Keywords
biosensing; gold nanoparticles; hybrid nanomaterials; molecular interactions; peptides
Categories
Funding
- National Natural Science Foundation of China [21605116]
- Zhejiang Provincial Natural Science Foundation of China [LR19H180001]
- Scientific Research Fund of National Health Commission [wkj-zj-1707]
- Public Projects of Zhejiang Province [2017C33193]
- Public Projects of Wenzhou [Y20160065, Y20160067, G20170011, G20170007]
- Government of Wenzhou [RX2016005]
- BOKU, Vienna
- NTU, Singapore
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Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing-related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide-AuNP-based bio-nano-technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide-gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide-gold nanomaterials with functional properties are discussed along with future challenges and opportunities.
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