Journal
ADVANCED MATERIALS
Volume 32, Issue 28, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202001172
Keywords
energy transfer; hepatocellular carcinoma detection; lanthanides; NIR-II dyes; NIR-II lifetime imaging
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Funding
- National Key R&D Program of China [2017YFA0207303]
- National Natural Science Foundation of China (NSFC) [21725502, 51961145403]
- Key Basic Research Program of Science and Technology Commission of Shanghai Municipality [17JC1400100, 19490713100]
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Deep tissue imaging in the second near-infrared (NIR-II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to tissue absorption and scattering hampers its application for accurate in vivo biosensing. Here, lifetime-based in situ hepatocellular carcinoma (HCC) detection in NIR-II region is presented using a tumor-microenvironment (peroxynitrite, ONOO-)-responsive lanthanide-cyanine Forster resonance energy transfer (FRET) nanosensor. A specially designed ONOO--responsive NIR-II dye, MY-1057, is synthesized as the FRET acceptor. Robust lifetime sensing is demonstrated to be independent of tissue penetration depth. Tumor lesions are accurately distinguished from normal tissue due to the recovery lifetime. Magnetic resonance imaging and liver dissection results illustrate the reliability of lifetime-based detection in single and multiple HCC models. Moreover, the ONOO- amount can be calculated according to the standard curve.
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