Journal
CHINESE JOURNAL OF CANCER RESEARCH
Volume 28, Issue 6, Pages 553-560Publisher
CHINESE JOURNAL CANCER RESEARCH CO
DOI: 10.21147/j.issn.1000-9604.2016.06.01
Keywords
WISP-1; cancer; clinical significance; metastasis; oncogene; tumor suppressor
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Funding
- Young Talents of Science and Technology Support Project of Colleges and Universities of Inner Mongolia Autonomous Region [NJYT-12-B21]
- Great Project of the Affiliated Hospital of Inner Mongolia Medical University, China [NYFY ZD 2012014]
- Beijing Municipal Administration of Hospitals' Youth Programme [QML20151003]
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Wnt-1 inducible signaling pathway-1 (WISP-1), also known as CCN-4, belongs to the connective tissue growth factor ( CTGF) family. WISP-1 is primarily expressed in embryonic stem cells and is involved in adult organ development. WISP-1 participates in many cellular processes, including proliferation, differentiation, apoptosis and adhesion. In addition, WISP-1 plays an important role in diverse pathophysiological processes, such as embryonic development, inflammation, injury repairs and cancers. Recent studies showed that WISP-1 was highly correlated with tumor progression and malignant transformation, whereas it played an oncogenic role in colorectal cancer, cholangiocarcinoma, hepatocellular carcinoma and breast cancer. However, interestingly, WISP-1 exerts a tumor-suppressing role in lung and prostate cancers. WISP-1 promotes cell proliferation, adhesion, motility, invasion, metastasis and epithelial-to-mesenchymal transition via particular signaling pathways. In this review, we discussed the structure, expression profile, functions, clinical significance and potential mechanisms of WISP-1 in cancer and non-neoplastic diseases.
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