Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 30, Issue 38, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202003069
Keywords
anticancer bioactivity; black phosphorus; mineralization; surface functionality; 2D materials
Categories
Funding
- National Natural Science Foundation of China [31800832, 61975065, 11904132, 31971368, 31900985]
- Guangdong Special Support Program [2017TX04C096]
- Leading Talents of Guangdong Province Program [00201520]
- Guangdong Basic and Applied Basic Research Foundation [2019B151502035]
- Fundamental Research Funds for the Central Universities [21619323]
- City University of Hong Kong Strategic Research Grant (SRG) [7005264]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [CityU 11205617]
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Biodegradable inorganic nanomaterials have opened new perspectives for cancer therapy due to their inherent anticancer activity. Black phosphorus nanosheets (BPs) with their unique bioactivity have recently been identified as promising cancer therapeutic agents but their application is hampered by the difficulty in surface functionalization. Herein, an in situ calcium phosphate (CaP) mineralization strategy is described to enhance the anticancer activity of BPs. By using BPs as the phosphate sources and growth templates, the synthesized CaP-mineralized BPs (CaBPs) retain the intrinsic properties of BPs and at the same time have high loading capacities for various fluorophores to enable effective bioimaging and tracing. Compared to BPs, CaBPs exhibit enhanced and selective anticancer bioactivity due to the improved pH-responsive degradation behavior and intracellular Ca(2+)overloading in cancer cells. Furthermore, CaBPs specifically target mitochondria and cause structural damage, thus leading to mitochondria-mediated apoptosis in cancer cells. After intravenous injection, CaBPs target orthotopic breast cancer cells to inhibit tumor growth without giving rise to adverse effects or toxicity. The results demonstrate the great potential of CaBPs as targeted anticancer agents and the CaP mineralization approach provides a versatile surface functionalization strategy for nanotherapeutic agents.
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