Journal
CHINESE CHEMICAL LETTERS
Volume 27, Issue 7, Pages 1067-1072Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2016.03.032
Keywords
Curcumin dihydropyrimidinones/thiones/imines; Microwave irradiations; Antioxidant capacity; Anti-inflammatory activity
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Funding
- Madhya Pradesh Council of Science and Technology, Bhopal, India [4468/CST/RD/2010]
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Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocon-densation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation. The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent. All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity. Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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