Journal
ACS CHEMICAL NEUROSCIENCE
Volume 11, Issue 17, Pages 2513-2522Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.0c00426
Keywords
Alzheimer's disease; tau proteins; neurofibrillary tangles; neuroimaging agents; positron emission tomography
Funding
- MGH Scholars Fund
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Neurofibrillary tangle (NFT) imaging methods at the distinct scales of atomic and whole-brain resolutions have coevolved rapidly. Linking these two areas of research provides insight into how and why certain tau radiotracers, using positron emission tomography (PET), bind selectively to certain morphological forms of the NFT fibril. In this Review, a brief history and background for each research area is presented leading to a summary of the current state of knowledge, with a synopsis of PET NFT radiotracers and an outlook for near-term research efforts. The continued integration of information provided at the level of each of these scales of resolution will catalyze the next generation of clinical imaging technique development and enhance our interpretations of them.
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