Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 33, Pages 36917-36927Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c09952
Keywords
oxygen vacancy defects; nanotheranostic agent; catalytic activity; MRI contrast enhancement; oxygen self-supplement
Funding
- Taishan Scholars Construction Engineering [tsqn20161047, tsqn201909144]
- Natural Science Foundation of Anhui Province [1808085MB38]
- National Natural Science Foundation of China [31771284, 81401518, 31430028, 81630019]
- Shandong Provincial Natural Science Foundation [ZR2016JL026]
- Key Research and Development Plan of Shandong Province [2018GSF118230]
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This work finds that Fe3O4 nanoclusters can rearrange by Gd doping and then self-assemble to a hollow magnetic nanocluster (HMNC), providing larger magnetic moments to obtain an excellent MRI capability and increasing the number of oxygen vacancies in HMNC. The hollow structure makes platinum(IV) prodrugs effectively load into HIVING. Second, plenty of oxygen vacancy defects can capture oxygen molecules, enhance the catalytic activity of HMNC, and then promote intracellular ROS generation. On the basis of this, a targeting iRGD-labeled HMNC nanosystem (iHMNCPt-O-2) is developed through loading oxygen molecules and platinum(IV) prodrugs for chemo- and chemodynamic therapy of cancer. This nanosystem shows an excellent response ability to weak acid and GSH, which can cause a series of cascade reactions in a cell. These cascade reactions are dramatically enhanced at the intracellular ROS level, cause mitochondria and DNA damage, and then induce cancer cell death. Besides, systemic delivery of iHMNCPt-O-2 significantly enhanced the MRI contrast signal of tumors and improved the quality of MR images, accurately diagnosing tumors. Therefore, this work provides a novel method for accelerating the Fenton-like reaction and enhancing the MRI capability and fabricates a promising all-in-one system to overwhelm the problems of cancer theranostic.
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