Journal
CHINESE CHEMICAL LETTERS
Volume 27, Issue 1, Pages 168-172Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2015.09.020
Keywords
PS-TBD; 1H-Pyrazole; Antimicrobial activity; Antioxidant activity
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Funding
- UGC, New Delhi
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A general protocol has been developed for the facile construction of titled derivatives via three component reaction between 3-substituted phenyl-1H-pyrazole-4-carbaldehyde, malononitrile and various Michael donors in presence of 5 mol% polystyrene supported 7-methyl-1,5,7-triazabicyclo-[4.4.0]dec-5-ene (PS-TBD). PS-TBD was reused for at least five runs with nearly constant catalytic activity. All compounds were screened for antimicrobial and antioxidant activities. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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