Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 31, Pages 34505-34513Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c04666
Keywords
electrochemotherapy; piezoelectric; cancer; selenium; apoptosis
Funding
- National Key R&D Program of China [2018YFC1105304, 2018YFC1105301]
- National Natural Science Foundation of China [51932002, 31771080, 51702104, 51903087, 51772106]
- Science and Technology Innovation Project of Foshan [2018IT100101]
- Natural Science Foundation of Guangdong Province [2016A030308014]
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Cancer residues around the surgical site remain a significant cause of treatment failure with cancer recurrence. To prevent cancer recurrence and simultaneously repair surgery-caused defects, it is urgent to develop implantable biomaterials with anticancer ability and good biological activity. In this work, a functionalized implant is successfully fabricated by doping the effective anticancer element selenium (Se) into the potassium-sodium niobate piezoceramic, which realizes the wireless combination of electrotherapy and chemotherapy. Herein, we demonstrate that the Se-doped piezoelectric implant can cause mitochondrial damage by increasing intracellular reactive oxygen species levels and then trigger the caspase-3 pathway to significantly promote apoptosis of osteosarcoma cells in vitro. Meanwhile, its good biocompatibility has been verified. These results are of great importance for future deployment of wireless electro- and chemostimulation to modulate biological process around the defective tissue.
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