Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 29, Pages 32301-32311Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c06949
Keywords
tumor immune microenvironment; fever-inducible nanocomposite; vascular normalization; TAMs reprogramming; breast cancer therapy
Funding
- National Natural Science Foundation of China [81873017]
- Key Medical Youth Talent Project of Jiangsu Province [QNRC2016631]
- Six Talent Peak Project of Jiangsu Province [YY-0282019]
- Key Research Project of Jiangsu Provincial Academy of Traditional Chinese Medicine [BM2018024-2019002]
- Jiangsu Government Scholarship for Overseas Studies
Ask authors/readers for more resources
A fever-mimic response capable of recruiting reprogrammed macrophages holds great potential in the engineering of the tumor microenvironment (TME). Low-temperature photothermal therapy (LT-PTT) can maintain tumors at a fever-like temperature (<45 degrees C) temporarily; however, it still faces several challenges in efficient regulation of TME because of reciprocal cross-talk between the bypass pathways. Here, we report a synergistic engineering of TME through an enhanced activation of a fever-mimic response based on both LT-PTT and tumor vascular normalization. Such engineering is achieved by a fever-inducible lipid nanocomposite (GNR-T/CM-L), which produces mild heat (similar to 43 degrees C) and sequentially releases multicomponents to cooperatively upregulate interferon-gamma under NIR irradiation, forming a bidirectionally closed loop for downstream M1 tumor-associated macrophage polarization and promoting the inhibition of the tumor growth. In proof-of-concept studies, GNR-T/CM-L demonstrated efficient tumor ablation in breast tumor xenograft-bearing mice and significantly prolonged their survival period. It paves an avenue to precisely reprogram TME for efficient cancer therapy through synergistic pathways of creating fever-like responses in the tumor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available