Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 28, Pages 31195-31204Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c07849
Keywords
SALDI-MS; DIOS; NIMS; doping; detection; rapid; mass spectrometry
Funding
- Australian Research Council [LP150100984]
- CSIRO Manufacturing
- Australian Government RTP scholarship
- Partnership for Clean Competition [2015R3000168G]
- Office of the Chief Executive
- Australian Research Council [LP150100984] Funding Source: Australian Research Council
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Novel doping agents and doping strategies are continually entering the market, placing a burden on analytical methods to detect, adapt, and respond to subtle changes in the composition of biological samples. Therefore, there is a growing interest in rapid, adaptable, and ideally confirmatory analytical methods for the fight against doping. Nanostructured silicon (nano-Si)-based surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) can effectively address this need, allowing fast and sensitive detection of prohibited compounds used in sport doping. Here, we demonstrate the detection of growth hormone peptides, anabolic-androgenic steroids, and narcotics at low concentrations directly from biological matrices. Molecular confirmation was performed using the fragmentation data of the structures, obtained with the tandem mass spectrometry capabilities of the SALDI instrument. The obtained data were in excellent agreement with those obtained using leading triple quadrupole liquid chromatography-mass spectrometry instruments. Furthermore, nano-Si SALDI-MS has the capacity for high-throughput analysis of hundreds of biological samples, providing opportunities for real-time MS analysis at sporting events.
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