Journal
ACS OMEGA
Volume 5, Issue 13, Pages 7418-7423Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c00032
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Funding
- Ratchadapiseksompot Fund from Chulalongkorn University (CU) [GCE 62018 23004-1]
- Development and Promotion of Science and Technology Talents Project (DPST)
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In this work, the preparation of novel calcium citrate (CaCit) nanoparticles (NPs) has been disclosed and the use of these NPs as Trojan carriers has been demonstrated. The concentration ratio between calcium ions and citrate ions was optimized, yielding spherical NPs with size in the range of 100-200 nm. Additionally, a fluorescent dye, fluorescein isothiocyanate (FITC), was successfully encapsulated by the coprecipitation method. The products were characterized by thermogravimetric analysis and scanning electron microscopy. The cellular uptake was investigated by incubating the synthesized fluorescent-tagged NPs with human keratinocytes using a confocal microscope. The accumulation of the FITC in the cells suggested that the CaCit NPs can potentially be used as novel drug carriers.
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