Journal
BLOOD
Volume 125, Issue 17, Pages 2621-2629Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-09-570192
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Funding
- New York State Department of Health
- National Institutes of Health from the National Institute of Diabetes and Digestive and Kidney Diseases [DK056638]
- National Institutes of Health from the National, Heart, Lung and Blood Institute [HL069438]
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The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and proliferation. Anatomic localization of the niche is a dynamic unit from the developmental stage that allows proliferating HSCs to expand before they reach the bone marrow where they adopt a quiescent phenotype that protects their integrity and functions. Recent studies have sought to clarify the complexity behind the HSC niche by assessing the contributions of specific cell populations to HSC maintenance. In particular, perivascular microenvironments in the bone marrow confer distinct vascular niches that regulate HSC quiescence and the supply of lineage-committed progenitors. Here, we review recent data on the cellular constituents and molecular mechanisms involved in the communication between HSCs and putative niches.
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