Journal
CLINICAL KIDNEY JOURNAL
Volume 13, Issue 3, Pages 281-286Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ckj/sfz171
Keywords
acute interstitial nephritis; CD69; Fx1A; LRP2; megalin; membranous nephropathy; proteinuria
Categories
Funding
- ERA-PerMed-JTC2018 (KIDNEY ATTACK) [AC18/00064, AC18/00071]
- ISCIII-RETIC REDinREN FEDER funds [RD016/0009]
- Fundacion Renal Inigo Alvarez de Toledo (FRIAT)
- Comunidad de Madrid [CIFRA2 B2017/BMD-3686]
- Rio Hortega program of ISCIII
- [PI16/02057]
- [PI19/00588]
- [PI19/00815]
- [DTS18/00032]
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In this issue of Clinical Kidney Journal, Gamayo et al. describe two cases of anti-low-density lipoprotein receptor-related protein 2 (LRP2) nephropathy. This is a recently described entity that has features of both tubulointerstitial disease and segmental membranous nephropathy. The originality of the present report consists of the association of a disease thought to be rare (only 13 in prior described patients, 11 in the past year) with B-cell lymphoproliferative disease. Together with the finding of a third case among 224 elderly patients studied, this raises the issue of the underdiagnoses of LRP2 nephropathy, on top of the potential association to B-cell malignancy. We now put these findings in context within the wider frame of autoimmunity against megalin/LRP2 and related antigens such as Fx1A and CD69.
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