Journal
PATHOGENS
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/pathogens9040252
Keywords
vaccines; adjuvants; inflammasomes; innate immunity; cytokines
Categories
Funding
- [IE-2393.2019.4]
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Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1 beta and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed.
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