Journal
ANTIOXIDANTS
Volume 9, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antiox9030231
Keywords
lipid peroxidation; LPIP; natural products; bioactive compounds; in vitro
Funding
- FCT/MCTES [UIDB/50006/2020]
- FCT [UID/MAR/04292/2019]
- European Union through EASME Blue Labs project AMALIA, Algae-to-MArket Lab IdeAs [EASME/EMFF/2016/1.2.1.4/03/SI2.750419]
- European Union through project VALORMAR (Mobilizing R&TD Programs, Portugal 2020) - COMPETE [POCI-01-0247-FEDER-024517]
- European Union through Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate [Centro-01-0145-FEDER-000018]
- Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund [SAICTPAC/0019/2015-LISBOA-01-0145-FEDER-016405]
- European Union through project Valorizacao dos subprodutos do processo biotecnologico de producao de esqualeno e DHA pela microalga Aurantiochytrium sp (AlgaValue) [17680]
- ANI-Agencia Nacional de Inovacao, S.A.
- FEDER-Fundo Europeu de Desenvolvimento Regional
- [SFRH/BD/139763/2018]
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Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms' health and on consumer products' quality and safety. Therefore, it has been the subject of extensive scientific research concerning the possibilities to reduce it, both in vivo and in nonliving organic matrices. It can be started by a variety of oxidants, by both ROS-dependent and -independent pathways, all of them reviewed in this document. Another feature of this reaction is the capacity of lipid peroxyl radicals to react with the non-oxidized lipids, propagating the reaction even in the absence of an external trigger. Due to these specificities of lipid peroxidation, regular antioxidant strategies-although being helpful in controlling oxidative triggers-are not tailored to tackle this challenge. Thus, more suited antioxidant compounds or technologies are required and sought after by researchers, either in the fields of medicine and physiology, or in product development and biotechnology. Despite the existence of several laboratory procedures associated with the study of lipid peroxidation, a methodology to perform bioprospecting of natural products to prevent lipid peroxidation (a Lipid Peroxidation Inhibitory Potential assay, LPIP) is not yet well established. In this review, a critical look into the possibility of testing the capacity of natural products to inhibit lipid peroxidation is presented. In vitro systems used to peroxidize a lipid sample are also reviewed on the basis of lipid substrate origin, and, for each of them, procedural insights, oxidation initiation strategies, and lipid peroxidation extent monitoring are discussed.
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