Journal
BIOMOLECULES
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/biom10040591
Keywords
YB-1; YBX1; YB-2; YB-3; Y-box-binding proteins; mRNP; RNA; translation regulation; stability regulation
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Funding
- Russian Science Foundation [19-74-20129]
- Russian Foundation for Basic Research [18-34-00359, 19-34-90067]
- Russian Science Foundation [19-74-20129] Funding Source: Russian Science Foundation
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Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell, tissue, or the whole organism. This review describes the involvement of YB proteins in RNA-dependent processes, such as mRNA packaging into mRNPs, mRNA translation, and mRNA stabilization. In addition, recent data on the structural peculiarities of YB proteins underlying their interactions with nucleic acids are discussed.
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