Journal
VACCINES
Volume 8, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/vaccines8010139
Keywords
virus-like particles; nanocarrier; recombinant vaccine
Categories
Funding
- National natural Science Foundation of China [U1705283, 81971932, 31670935]
- National Science and Technology Major Projects for Major New Drugs Innovation and Development [2018ZX09738-008]
- Fujian natural Science Foundation [2017J07005]
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Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural proteins of a virus in the absence of genetic material. Having similar morphology to natural viruses but lacking any pathogenicity or infectivity, VLPs have gradually become a safe substitute for inactivated or attenuated vaccines. VLPs can achieve tissue-specific targeting and complete and effective cell penetration. With highly ordered epitope repeats, VLPs have excellent immunogenicity and can induce strong cellular and humoral immune responses. In addition, as a type of nanocarrier, VLPs can be used to display antigenic epitopes or deliver small molecules. VLPs have thus become powerful tools for vaccinology and biomedical research. This review highlights the versatility of VLPs in antigen presentation, drug delivery, and vaccine technology.
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