Journal
TRANSLATIONAL LUNG CANCER RESEARCH
Volume 9, Issue 2, Pages 188-+Publisher
AME PUBLISHING COMPANY
DOI: 10.21037/tlcr.2020.02.14
Keywords
PD-1/L1 inhibitors; non-small cell lung cancer (NSCLC); front-line; network meta-analysis (NMA)
Categories
Funding
- National Key R&D Program of China [2017YFC0907900, 2017YFC0907903]
- China National Science Foundation [81871893]
- Key Project of Guangzhou Scientific Research Project [201804020030]
- High-level university construction project of Guangzhou medical university [20182737, 201721007, 201715907, 2017160107]
- National key R D Program [2017YFC0907903, 2017YFC0112704]
- Guangdong high level hospital construction reaching peak plan
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Background: This Bayesian network meta-analysis (NMA) was conducted to compare efficacy and safety of programmed death 1/ligand 1 (PD-1/L1) inhibitors in previous untreated advanced non-small cell lung cancer (NSCLC) patients. Methods: Eligible studies evaluating first-line anti-PD-1/L1 based regimens in advanced NSCLC patients were included. Overall survival (OS), progression free survival (PFS), objective response rate (ORR), as well as treatment-related severe adverse events (tr-SAE) were synthesized within the Bayesian framework. Subgroup analysis was conducted according to PD-L1 expression. Results: Twelve studies including 7,490 patients and 9 treatment strategies were enrolled in this study. For the PD-L1 expression non-selective patients, all chemo-immunotherapies were significantly better than chemotherapy for prolonging OS and PFS, except for caremlizumab plus chemotherapy (HR=0.72) failed to show advantages for OS. In addition, pembrolizumab plus chemotherapy showed better PFS than nivolumab plus ipilimumab (HR=0.66). In PD-L1 >= 50% patients, all immunotherapy was better than chemotherapy for OS, except for nivolumab (HR=0.83) and nivolumab plus ipilimumab (HR=0.70). For PFS, pembrolizumab plus chemotherapy (HR=0.39), atezolizumab plus chemotherapy (HR = 0.47) and pembrolizumab (HR = 0.67) were significantly better than chemotherapy. In PD-L1 1-49% patients, pembrolizumab plus chemotherapy (HR=0.52) and atezolizumab plus chemotherapy (HR=0.70) were better than chemotherapy for PFS. In the PD-L1 positive or negative group, all included corresponding regimens were equivalence according to OS and PFS. Conclusions: We conducted a systematic comparison of first line immunotherapy for advanced NSCLC. Chemo-immunotherapies were better than chemotherapy and mono-immunotherapies in most patients. Pembrolizumab might have better efficacy than other PD-1/L1 inhibitors.
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