Energy balance and fitness in adult survivors of childhood acute lymphoblastic leukemia

There is limited information on body composition, energy balance, and fitness among survivors of childhood acute lymphoblastic leukemia (ALL), especially those treated without cranial radiation therapy (CRT). This analysis compares these metrics among 365 ALL survivors with a mean age of 28.6 +/- 65.9 years (149 treated with and 216 without CRT) and 365 age-, sex-, and race-matched peers. We also report risk factors for outcomes among survivors treated without CRT. Male survivors not exposed to CRT had abnormal body composition when compared with peers (% body fat, 26.2 +/- 8.2 vs 22.7 +/- 7.1). Survivors without CRT had similar energy balance but had significantly impaired quadriceps strength (-21.9 +/- 6.0 Newton-meters [Nm]/kg, 60 degrees/s) and endurance (-11.4 +/- 4.6 Nm/kg, 300 degrees/s), exercise capacity (-2.0 +/- 2.1 ml/kg per minute), low-back and hamstring flexibility (-4.7 +/- 1.6 cm), and dorsiflexion range of motion (-3.1 +/- 0.9 degrees) and higher modified total neuropathy scores (+1.6 +/- 1.1) than peers. Cumulative asparaginase dose >= 120 000 IU/m(2) was associated with impaired flexibility, vincristine dose >= 39 mg/m(2) with peripheral neuropathy, glucocorticoid (prednisone equivalent) dose >= 8000 mg/m(2) with hand weakness, and intrathecal methotrexate dose >= 225 mg with dorsiflexion weakness. Physical inactivity was associated with hand weakness and decreased exercise capacity. Smoking was associated with peripheral neuropathy. Elimination of CRT from ALL therapy has improved, but not eliminated, body-composition outcomes. Survivors remain at risk for impaired fitness.