Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.00239
Keywords
autophagy; mitophagy; aging; mitophaging; monogenic disorders; interventions
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Funding
- German Research Foundation (Forschungsstipendium) [BA 6276/1-1, 7016-00230B]
- Lundbeck foundation [R303-2018-3159]
- Nordea Foundation [02-2017-1749]
- Novo Nordisk Foundation [NNF17OC0027812]
- Danish Cancer Society [R167-A11015_001]
- Independent Research Fund Denmark [7016-00230B]
- Neye Foundation
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Maintaining mitochondrial health is emerging as a keystone in aging and associated diseases. The selective degradation of mitochondria by mitophagy is of particular importance in keeping a pristine mitochondrial pool. Indeed, inherited monogenic diseases with defects in mitophagy display complex multisystem pathologies but particularly progressive neurodegeneration. Fortunately, therapies are being developed that target mitophagy allowing new hope for treatments for previously incurable diseases. Herein, we describe mitophagy and associated diseases, coin the term mitophaging and describe new small molecule interventions that target different steps in the mitophagic pathway. Consequently, several age-associated diseases may be treated by targeting mitophagy.
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