Journal
ADDITIVE MANUFACTURING
Volume 33, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addma.2020.101162
Keywords
3D printing; 3D bioprinting; Material extrusion; Hydrogel; Supramolecular; Self-assembly; Low molecular weight gel; LMWG; Self-assembled fibrillar network; SAFIN; Fiber; Wet spinning; Solvent exchange; Diffusion; Coagulation; Carbohydrate; Sugar; Saccharide; Amphiphile; N-Alkyl aldonamide; N-Heptyl-D-galactonamide
Funding
- French National Research Agency [ANR-15-CE07-0007-01]
- Region Occitanie - France [16007407/MP0011594]
- European Union [FEDER-35477]
- HoliFAB project - European Union's Horizon 2020 research and innovation program [760927]
- MultiFAB project - FEDER European Regional Funds
- Agence Nationale de la Recherche (ANR) [ANR-15-CE07-0007] Funding Source: Agence Nationale de la Recherche (ANR)
- H2020 Societal Challenges Programme [760927] Funding Source: H2020 Societal Challenges Programme
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A fragile and non-thixotropic biocompatible low molecular weight gel is printed in 3D structures by a solvent exchange process. The 3D printing process is based on the continuous extrusion of a solution of a small amphiphile molecule, N-heptyl-D-galactonamide, in dimethylsulfoxide, that forms a gel in contact with water. The diffusion of water in the dimethylsulfoxide / N-heptyl-D-galactonamide solution triggers the self-assembly of the molecule into supramolecular fibers and the setting of the ink. The conditions for getting a well-defined pattern and the dimensions of the constructs have been determined. The resulting constructs can be easily dissolved, orienting its application as a sacrificial ink or a temporary support. This method opens the way to the injection and the 3D printing of other fragile and non-thixotropic supramolecular hydrogels.
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